The speed of technology in neuroscience as it impacts ethical and just decisions in the legal system needs to be understood by lawyers, judges, public policy makers, and the general public. The Massachusetts General Hospital Center for Law, Brain, and Behavior is an academic and professional resource for the education, research, and understanding of neuroscience and the law. Read more

Parcellating Cortical Functional Networks in Individuals

By Danhong WangRandy L BucknerMichael D FoxDaphne J HoltAvram J HolmesSophia StoeckleinGeorg LangsRuiqi PanTianyi QianKuncheng LiJustin T BakerSteven M StufflebeamKai Wang  Xiaomin WangBo Hong, and Hesheng Liu | Nature Neuroscience | November 9, 2015


The capacity to identify the unique functional architecture of an individual’s brain is a crucial step toward personalized medicine and understanding the neural basis of variation in human cognition and behavior. Here we developed a cortical parcellation approach to accurately map functional organization at the individual level using resting-state functional magnetic resonance imaging (fMRI). A population-based functional atlas and a map of inter-individual variability were employed to guide the iterative search for functional networks in individual subjects. Functional networks mapped by this approach were highly reproducible within subjects and effectively captured the variability across subjects, including individual differences in brain lateralization. The algorithm performed well across different subject populations and data types, including task fMRI data. The approach was then validated by invasive cortical stimulation mapping in surgical patients, suggesting potential for use in clinical applications.

Read the full journal article here.