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The speed of technology in neuroscience as it impacts ethical and just decisions in the legal system needs to be understood by lawyers, judges, public policy makers, and the general public. The Massachusetts General Hospital Center for Law, Brain, and Behavior is an academic and professional resource for the education, research, and understanding of neuroscience and the law. Read more

Genetic Influences on Schizophrenia and Subcortical Brain Volumes: Large-Scale Proof of Concept

By Barbara FrankeJason L. SteinStephan RipkeVerneri AnttilaDerrek P. HibarKimm J. E. van HulzenAlejandro Arias-VasquezJordan W. SmollerThomas E. NicholsMichael C. NealeAndrew M. McIntoshPhil LeeFrancis J. McMahonAndreas Meyer-LindenbergManuel MattheisenOle A. AndreassenOliver GruberPerminder S. SachdevRoberto Roiz-SantiañezAndrew J. SaykinStefan EhrlichKaren A. MatherJessica A. TurnerEmanuel SchwarzAnbupalam Thalamuthu, et al. | Nature Neuroscience | February 1, 2016

Abstract:

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.

Read the full paper here.